Behold, the Lion/Tigress hybrid: the Liger. For real. A Liger is the product of a male Lion and a female Tigress, whereas a Tigon is produced when a male Tiger is mated with a female Lioness. In nature, this type of combo would never take place, but in captivity, anything goes.
Watch this video of Sinbad the Liger. He is also the largest cat ever at 900 lbs – likely the result of hybrid giantism: